What kind of medicine should you take without eating seafood? A complete analysis of drug-seafood interactions
Seafood is loved for its delicious taste and rich nutrition, but taking some drugs with seafood may cause adverse reactions or even poisoning. This article will be compiled based on the popular health topics on the Internet in the past 10 days.List of common drugs that are contraindicated with seafood, and provide scientific advice.
1. Why can’t certain medicines be eaten with seafood?

Seafood is rich in protein, purines and trace elements, which may react chemically with pharmaceutical ingredients, resulting in:
1. The efficacy of the medicine is reduced or ineffective
2. Increase the metabolic burden on liver and kidneys
3. Cause allergic or toxic reactions
| drug type | Representative medicine | interaction mechanism | risk symptoms |
|---|---|---|---|
| antibiotics | Cefixime, tetracycline | Seafood calcium ions affect drug absorption | Reduced drug efficacy, skin rash |
| antigout medicine | Allopurinol | Seafood high in purines offsets medicinal effects | Gout attacks worsen |
| thyroid medication | Levothyroxine Sodium | Iodine content in seafood interferes with drug efficacy | Hyperthyroidism/hypothyroidism symptoms fluctuate |
| anticoagulant drugs | warfarin | Seafood vitamin K antagonism | Abnormal coagulation function |
2. Recent hot-search related cases (last 10 days)
1.#A man went to ICU after eating crabs after taking cephalosporin#(Tik Tok hot list)
2.#Gout patients will experience double pain when eating seafood and drinking medicine#(Weibo health topic)
3.#Experts remind that seafood dispensing needs to be done 4 hours apart#(Today’s hot headlines)
3. Scientific medication recommendations
| drug type | safety interval | alternative protein sources |
|---|---|---|
| antibiotics | At least 2 hours after taking the medicine | chicken, tofu |
| antigout medicine | Avoid eating while taking medication | Eggs, low-fat milk |
| thyroid medication | Take the medicine on an empty stomach in the morning and a small amount at dinner | freshwater fish |
4. Precautions for special groups of people
1.People with allergies: Avoid the combination of penicillins + crustacean seafood
2.Liver disease patients: Seafood + rifampicin may aggravate liver damage
3.pregnant woman: Eating the anthelmintic drug metronidazole with seafood may cause vomiting
5. Health Tips
1. Carefully read the "Dietary Contraindications" in the instructions before taking the medicine.
2. When in doubt, consult a doctor or pharmacist
3. If you feel unwell, stop eating immediately and seek medical advice.
4. Choose fresh seafood and avoid high-risk ingredients such as dead crabs
Note: The data in this article are based on the National Medical Products Administration, WHO food safety guidelines and medication guidance from tertiary hospitals. Please follow your doctor’s advice for specific medication.
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